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ea0019p141 | Diabetes, Metabolism and Cardiovascular | SFEBES2009

Epigenetic changes of the hypothalamic glucocorticoid receptor gene occur in the ovine foetus in conjunction with periconceptional undernutrition

Stevens A , Cook A , Rumball C , Oliver M , Connor K , Challis J , Bloomfield F , White A

Glucocorticoids are known to have a role in the programming of appetite regulation but the mechanisms have not been fully delineated. This study examined the effect of maternal undernutrition on glucocorticoid receptor (GR) as a key regulator of the appetite regulating neuropeptides, proopiomelanocortin (POMC) and neuropeptide Y (NPY) in the hypothalamus.Ewes were undernourished (UN, n=4) for 30 days pre- and 60 days post-mating or given normal fe...

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ea0019p142 | Diabetes, Metabolism and Cardiovascular | SFEBES2009

Periconceptional undernutrition is associated with epigenetic changes in the Proopiomelanocortin (POMC) gene in the hypothalamus of foetal sheep

Stevens A , Cook A , Rumball C , Oliver M , Connor K , Challis J , Bloomfield F , White A

Maternal undernutrition influences the development of diseases such as obesity and diabetes in the adult offspring. Programming of key genes involved in hypothalamic appetite regulation such as proopiomelanocortin (POMC) and neuropeptide Y (NPY) may affect energy balance in adulthood. These changes may occur by alterations in gene expression or epigenetic changes including histone acetylation and DNA methylation. This study aims to examine the effects of maternal undernutritio...

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Endocrine Abstracts

Epigenetic changes of the hypothalamic glucocorticoid receptor gene occur in the ovine foetus in conjunction with periconceptional undernutrition

Periconceptional undernutrition is associated with epigenetic changes in the Proopiomelanocortin (POMC) gene in the hypothalamus of foetal sheep

BiosciAbstracts